Hugo Rodallega opened his Fulham goals account against the club he left in the summer to set Martin Jol's side on their way to a 2-1 away win, their first of the season in the Barclays Premier League.
It meant that for the second campaign in a row the Cottagers have broken their away duck at the DW Stadium, and the result lifted Fulham into the top four, at least until Sunday.
Rodallega deservedly broke the deadlock in the 31st minute with a goal created by the excellent Dimitar Berbatov, and Damien Duff added a second goal midway through the second half before Arouna Kone scored an injury-time consolation for Wigan.
The main talking point of the early stages was an unfortunate moment for referee Lee Probert, who was the unintended victim of a full-blooded challenge between Steve Sidwell and Ben Watson.
The referee was well and truly floored and there was a lengthy delay while he received treatment, although he did see the funny side, waving a red card in jest.
Fulham had been threatening to make the breakthrough long before Rodallega's goal arrived, with Berbatov and Chris Baird going close, while at the other end Emmerson Boyce headed wide.
Berbatov expertly picked out the head of Rodallega for the opening goal, and graciously the striker chose not to celebrate, earning him applause from the home fans.
Wigan's Jordi Gomez hit the bar, and Kone squandered a clear opening.
Fulham scored their second after 68 minutes, substitute Bryan Ruiz teeing up the unmarked Duff for a clinical finish.
Berbatov was denied by an accomplished save from Ali Al Habsi before Wigan eventually found the net, Kone with a fine turn and shot. But with only two minutes of injury time remaining, the strike came too late for the hosts.